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medibles™ Expands its CBD-Drug Interaction Database, Cross-Examining More Than 750 Prescription Medications

Certain drugs interact with Cannabidiol; these interactions typically involve drugs metabolized by CYP450 enzymes and could possibly interact with CBD.

LOS ANGELES, JAN. 06, 2022 /PRNewswire/ — medibles™, medibles, the leading next-generation subscription-based platform, today announced the expansion of its CBD-Drug Interaction (CBDDI) database to deliver a truly personalized approach to taking CBD oil for health and wellness. medibles’ online health assessment can now cross-examine more than 750+ prescription medications to ensure each CBD recommendation considers that certain drugs interact with Cannabidiol; these interactions typically involve drugs that are metabolized by CYP450 enzymes and could possibly interact with CBD. 

“When someone takes a medication or other substance, their body has to break it down. Drug metabolism happens throughout the body, such as in the gut, but the liver does a big part of the job. A family of enzymes called cytochrome P450 (CYP450) does the vital work of converting foreign substances to easily be eliminated from the body. But some medications or substances affect CYP450, either by slowing or speeding up drug metabolism. That change in metabolism rate can alter how someone’s body processes the medications or supplements they take — hence a drug interaction.” — Gregory L. Taylor, II, MD, Chief Medical Officer & Medical Advisory board member at medibles. “When consulting with a doctor, the Physician may not be familiar with CBD as a compound. Therefore, a safety precaution when discussing CBD is asking if any of the medications taken can interact with grapefruit.”

The “Grapefruit Test” is an excellent method to establish whether a medication will interact with CBD. Consequently, due to the novelty and the limited research conducted on CBD thus far, people should ask to do the “Grapefruit Test” with their doctor. The “grapefruit test” is asking a doctor if any of the medications being taken could be affected by eating grapefruits. Cannabidiol works in precisely the same manner chemically as a grapefruit in their body, just more powerful— in that, it could impact many widely used medicines. 

Certain medications interact with (CBD) Cannabidiol.

Some medications interact with CBD. These interactions typically involve medications that are metabolized by CYP450 enzymes and could interact with Cannabidiol (CBD). According to the Indiana University Department of Medicine, drugs known to use the CYP450 system are below.

  • Angiotension II blockers
  • HIV antivirals
  • Antihistamines
  • HMG CoA reductase inhibitors
  • Anti-epileptics
  • Oral hypoglycernic
  • Antidepressants
  • PPIs
  • Anesthetics
  • Prokinetics
  • Anti-psychotics
  • NSAIDs
  • Benzodiazepines
  • Sulfonylureas
  • Beta-blockers
  • Steroids
  • Calcium channel blockers

“When we launched our company in 2020, we quickly realized that we needed to expedite the expansion of our database as more people completed the CBD online health assessment. In addition, there are thousands of prescription medications on the market. We understand the importance of giving clients the tools they need to avoid unnecessary CBD-Drug interactions,” commented Bobby D. Ntoya, CEO at medibles. “Our medical advisory board and our on-staff of Bio-Health Specialists generate our CBD-Drug database by following the latest in Cannabis science and applying it to everyday use. We will always expand our database to grow it.”

To learn more about medibles or take the free online health assessment, please visit

About medibles 

medibles is a next-generation subscription-based platform provider that supplies CBD products such as edibles, capsules, concentrates, tinctures, and more for your health and wellness. We offer a personalized CBD program that provides an online health assessment using our proprietary algorithm, a doctor-recommended CBD regimen routine, and a monthly home delivery service. Our doctors, pharmacists, and other healthcare experts on our Medical Advisory Board created an online health assessment algorithm using combined years of professional expertise, science, and technology. Along with analyzed peer-reviewed scientific studies, current and ongoing research, more than thousands of potential medication interactions, and input provided by clients to recommend a monthly personalized CBD dosage regimen delivered to the customer. medibles is available on both iOS and Android, or visit our site. Follow us on LinkedinFacebookTwitterInstagram, or YouTube.


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Bobby Ntoya

medibles PR


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