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CBD for Pain

The research on cannabinoid CBD products and pain management has been up-and-coming. One notable one, Cannabinoids and Pain: New Insights From Old Molecules, assessed how well CBD worked to relieve chronic pain. The review looked at research studies performed from 1975 to 2018. The studies examined various types of pain, including cancer pain, neuropathic pain, and fibromyalgia. They found that CBD effectively alleviated overall pain management and didn’t cause adverse side effects. In addition, many studies on pain and cannabinoids have been done on the entire cannabis plant consisting of psychoactive tetrahydrocannabinol (THC) and non-psychoactive Cannabidiol (CBD). For example, a study reported in Neurotherapeutics proved that CBD Dosage treatment was therapeutic for individuals with neuropathic and general pain, usually by interacting with alpha-3 glycine receptors (which involves sensing pain) to reduce pain and inflammation.

Various research into the effectiveness of a CBD dosage used as a single treatment for general pain is still in progress. Cannabinoid is found in several research studies to regulate and control pain. However, research has shown that the interaction of THC, with Cannabidiol (CBD), in combination is a promising catalyst in reducing pain. In addition, it has been found that cannabinoids such as CBD may also indirectly affect its properties by working on a G-protein coupled receptor known as TRPV-1, or the vanilloid receptor known as a molecular pathway for various underlying diseases and pain. In layman terms, CBD essentially binds to the pain receptors and mediates the sensation of discomfort throughout the body, which provides a therapeutic benefit of acting as an anti-inflammatory and pain management.

Because CBD supports Anandamide, it is good to note that Anandamide is a notable endocannabinoid that effectively reduces pain. Anandamide is a lipid-based neurotransmitter that has been compared to the cannabinoid THC. However, research has shown that some people suffer from a clinical endocannabinoid deficiency. This condition limits the production of Anandamide in the right amounts needed to guarantee optimum state in the endocannabinoid system. CBD assists with this deficiency by supporting the natural production of Anandamide.

In addition, CBD has been proven to minimize the effects of conditions caused by pain, such as inflammation. Cannabinoids have a surprisingly notable impact on the body’s immune system because they interact with CB2 receptors associated with the immune system. Therefore, keeping the endocannabinoid system managed with consistent prescribed CBD dosing may help diminish the possibility of Regular / Chronic / and neuropathic pain.

There are a few approaches to managing pain with the use of CBD products. Whether it’s managing neuropathic pain that often occurs very quickly and involves intense short-term acute pain or severe chronic pain – that may be long-term in nature, patients are advised to use an admission technique that enables quick delivery of CBD into the bloodstream and the endocannabinoid system. With that said, Cannabidiol is lipid-soluble, which means absorption into the body is rapid, advantageous when there is a need for a quick onset relief. However, if pain is more chronic, some CBD products such as edibles have slow absorption depending on the dosage; the effects are felt more over an extended amount of time.

Although conflicting opinions continue to exist, most reviews concluded that cannabis and cannabinoids might play a significant role in pain management. While there isn’t conclusive research data to support CBD as the preferred method of pain management, scientists agree that these types of products have a lot of promise. CBD products might offer relief for many people who have acute or chronic pain, all without causing drug intoxication and dependence.

Resources and Studies

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/

https://link.springer.com/article/10.1007/s11481-021-10010-x

https://doi.org/10.3389/fphar.2018.01259

https://www.healthline.com/health/neuropathic-pain