Certain drugs interact with Cannabidiol; these interactions typically involve drugs metabolized by CYP450 enzymes and could possibly interact with CBD.
LOS ANGELES, April 11, 2025 /PRNewswire/ — As the wellness industry evolves, more people are turning to Cannabidiol (CBD) for relief, recovery, and resilience. But as with any active compound, CBD does not exist in a vacuum; it can interact with other medications, potentially altering how they affect your body. That’s why medibles™, the leading next-generation subscription-based CBD health platform, is proud to announce the continued expansion of its CBD-Drug Interaction (CBDDI) database, now capable of cross-referencing over 5,400 prescription medications.
At medibles, we believe that personalized wellness begins with safety and science. Our online health assessment now includes this robust drug interaction database to help users safely integrate CBD into their wellness routine, avoiding harmful drug interactions before they occur.
Why Drug Interactions with CBD Matter
“When someone takes a medication or other substance, the body works to break it down and eliminate it,” explains Dr. Gregory L. Taylor, II, Chief Medical Officer at medibles. “A family of enzymes called cytochrome P450 (CYP450) does much of this work, primarily in the liver. However, certain compounds, including CBD, can alter how this system works, speeding it up or slowing it down.”
This change in metabolic rate may cause the body to process drugs either too quickly, reducing their efficacy, or too slowly, increasing the risk of side effects. Because of this, CBD can potentially interact with a wide range of medications.
The “Grapefruit Test”: A Simple Safety Tip
Physicians may not always be up to date on CBD-related interactions, but there is a simple tool that patients and providers can use to assess potential risks: the Grapefruit Test.
“If your doctor says you should avoid grapefruit with your medication,” Dr. Taylor continues, “it’s a strong indication that CBD might also interact with that drug, because both compounds inhibit the same enzyme family.”
This test is especially useful for individuals taking medications where altered metabolism could pose a danger, such as heart medications, psychiatric drugs, and specific immunosuppressants.
Common Drug Classes That May Interact with CBD
Based on research from the Indiana University Department of Medicine, medications that rely on CYP450 metabolism and could be impacted by CBD include:
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Angiotensin II blockers
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HIV antivirals
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Antihistamines
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Statins (HMG-CoA reductase inhibitors)
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Anti-epileptics
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Oral hypoglycemics
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Antidepressants
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Proton pump inhibitors (PPIs)
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Anesthetics
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Prokinetics
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Antipsychotics
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NSAIDs (nonsteroidal anti-inflammatory drugs)
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Benzodiazepines
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Sulfonylureas
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Beta-blockers
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Steroids
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Calcium channel blockers
With so many medications on the market, any CBD regimen must be tailored to the individual. That’s where medibles™ steps in.
A Smarter Approach to CBD Personalization
“When we launched our company in 2019, we understood very early that personalization must include safety,” said Bobby D. Ntoya, CEO of medibles™. “We didn’t want to just recommend CBD—we wanted to ensure we were making recommendations grounded in science and compatible with real-world medical profiles.”
That’s why medibles created its AI-powered online health assessment, which cross-examines prescription medications, medical history, and wellness goals to generate a safe, custom-tailored CBD dosage plan. This plan is then reviewed by our team of Bio-Health Specialists, pharmacists, and physicians for accuracy and precision.
“Our Medical Advisory Board closely monitors emerging cannabis science and evolving drug data to expand our CBDDI database continuously,” adds Ntoya. “This ensures every medibles user receives a CBD protocol that’s not only effective, but also safe and scientifically sound.”
Take the First Step Toward Smarter CBD Use
Want to know if your medications are compatible with CBD? Take our free online health assessment today at https://medibles.io and receive a custom CBD plan that considers your health history, wellness goals, and prescription profile.
We also encourage you to discuss any new regimen with your healthcare provider, especially if your medications carry grapefruit warnings.
About medibles™
medibles™ is a next-generation subscription-based platform offering precision CBD solutions, including tinctures, capsules, edibles, and concentrates. Our proprietary online health assessment, built by licensed physicians, pharmacists, and wellness experts, creates a tailored, data-driven CBD plan for each user. Backed by a growing drug interaction database, medibles empowers customers to confidently incorporate CBD into their wellness routines without compromising safety.
Available on iOS, Android, and at medibles.io, our service delivers doctor-recommended CBD regimens to your doorstep each month.
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Media Contact:
Erika De Jesus
medibles™ PR
📧 bewell@medibles.io
📞 866-546-0694
SOURCE: medibles™